At the Sigi and Marilyn Ziering National Center for Newborn Screening, founded by and housed at Sheba, the blood of every baby born in Israel - more than 165,000 a year -- is screened during the first days of the child's life for a dozen debilitating and deadly metabolic and endocrinological diseases.

If treated properly during the first months of life, doctors can prevent mental retardation, irreversible neurological damage and even death caused by these diseases.

Dr. Shlomo Almashanu, director of the Center, says that his cutting-edge laboratory saves the live of a newborn baby every other day. "In the past year we identified and saved the lives of newborn children with congenital hypothyroidism, congenital adrenal hyperplasia, PKU, MSUD, glutaric aciduria, propionic acidemia, methylmalonic acidemia, tyrosinemia, homocystenuria, citrullinemia, MCAD and VLCAD. For each and every disorder screened, we have identified and saved lives, and we hope to expand our screening abilities to include additional diseases."

Dr. Almashanu is a clinical biochemical and molecular geneticist, board certified by the American Board of Medical Genetics. He trained at the Technion, and the University of Maryland and Johns Hopkins Medical Schools.

Below is an article from The Jerusalem Post about the opening of the center in 2008.

New center to screen all babies for metabolic disorders, at Sheba

Judy Siegel-Itzkovich, THE JERUSALEM POST, May 18, 2008

A modern center to screen the blood of all babies born in Israel for debilitating and deadly metabolic and endocrinological diseases has been dedicated at Sheba Medical Center at Tel Hashomer. Named for Sigi and Marilyn Ziering of Los Angeles, who donated much of the $7 million raised for the center, the vital project replaces and old screening facility and centralizes the testing of blood from all newborns regardless of race, religion or national origin. By next year, the Health Ministry will assume all the center's operating costs.

All 150,000 babies born each year around the country have a drop of blood taken from the heel of one foot a day after birth. If treated properly during the first months of life, doctors can prevent the mental retardation, blindness or death that might otherwise result from these diseases. The center has American-made, state-of-the-art technology and advanced work protocols provided by an international scientific advisory panel.

Marilyn Ziering, widow of Sigi, dedicated the center two weeks ago, accompanied by a 40-person mission of Sheba friends from the US West Coast.

"I am thrilled to be able to contribute to the health of Israel's kids in this way, she said. "I know laboratories, and this is a good laboratory!" she declared.

For the past half century, the Ziering family has owned and operated DPC Medical Technologies of California, a major diagnostic kit manufacturer.

Dr. Kenneth Pass, former director of New York State's neonatal screening program and a key advisor to the new Sheba lab, came to take part in the dedication. "Not only has it been an honor and a pleasure to help Israel get its screening center off the ground, but NY State benefited from this collaboration as well," he said. "I salute you for the magnificent center you have built to the highest international standards."

Dr. Shlomo Almashanu, director of the Sigi and Marilyn Ziering Israel National Center for Newborn Screening at the Sheba Medical Center, told the 100 guests at the dedication that in recent months the center had identified and saved the lives of newborns with congenital hypothyroidism, PKU, congenital adrenal hyperplasia and VLCAD.

"We even caught a confirmed case of glutaric aciduria type I in a baby born to a Palestinian mother, who told the genetic counselor about three previous babies who had died without a diagnosis," he said.