The Bone Marrow Transplantation Unit is located within the Pediatric Hemato-Oncology Department and consists of four private rooms all equipped with HEPA Filtration Systems. We perform about 25 transplantations a year. Autologous Transplants are performed on patients with solid tumors. Allogeneic Transplants are performed on patients with Leukemia, Hematological Disorders, Bone Marrow Failure, Metabolic Diseases and Immunodeficiencies. Cord Blood Cell Transplants are also performed. Alternative Donor Transplants with partially matched related donors using T-Cell Depletion and CD34 positive selection may be performed in the haploidentical setting. Unrelated Stem Cell Transplantations are performed from donors recruited through the National Marrow Donor Program (we are full members in this organization) and other registries. The search for donors is aided by the service of a modern HLA lab headed by Dr. Ron Lowental performing high resolution DNA testing for class 2 antigens and intermediate/high resolution for class 1 antigens.  Engraftment, relapse, minimal residual disease tests are performed in the modern molecular laboratory headed by Dr Amariglio. We regularly report the transplantations we perform to the International Bone Marrow Transplant Registry (IBMTR) and to the European Group for Blood and Marrow Transplantation (EBMT).

Last year we successfully performed a Cord Blood Transplantation to a child with Fangoni's Anemia in which the source of the graft was from a new born who resulted from a pregnancy that was initiated after Pre-Implantation Genetic Diagnosis (PGD), where single cell PCR confirmed HLA compatibility and a disease free state.