Systemic and dietary advanced glycation end products in type 2 diabetes-related cognitive decline and incident dementia: effects on Alzheimer's pathology and cerebrovascular disease.

Description: This study will examine, in elderly subjects diagnosed with Type 2 diabetes, the hypothesis that dietary and blood serum advanced glycation end products (AGEs) are related to impaired cognition through an association with Alzheimer’s disease and cerebrovascular neuropathologies, and that serum AGEs mediate the associations of dietary AGEs with cognition and neuropathology. This hypothesis will be tested through long term repeated physical, cognitive evaluations, and through blood sample analysis and neuro-imaging techniques.

Contact Person: Yuval Berman yuval.berman@sheba.health.gov.il

PI: Dr. Ramit Ravona-Springer