Outlines
Laboratory for Clinical and Applied Research
Dr. Michal Besser, Head
Research and clinical development of advanced cellular immune-therapy.
- Ongoing clinical studies – cell immune-therapies
- TIL* for treatment of metastatic melanoma
- TIL* for treatment of ovary cancer
- CAR-T** for treatment of hematological malignancies
- Applied clinical research
- Development of immune-therapy against mutations in tumor cells (Neo-Antigens)
- Research and development of next generation TIL* treatment
- Genetic engineering of lymphocytes with novel CAR-T** for treatment of various malignancies.
- Molecular mechanism of apoptosis of melanoma cells
- Research and development of skin substitutes for treatment of burns
- Operation of GMP*** laboratory for development and production of cell
based therapies.
- Tumor infiltrating lymphocytes
- Chimeric antigen receptor
- Good manufacturing practice
Research and Development Laboratory
Prof. Gal Markel, Head
Advanced clinical and applied research in various aspects of cancer immunology and immuno- therapy.
- Characterization of immune profile of patients for developing of customized treatments
- Identifying evasive mechanisms of tumors from the immune system as targets for developing new drugs.
- The influence of metabolism of the tumor on the immune system.
- Integrated data bases of cancer patients for research and development of new treatments.
- The role of microRNA in malignant development.
