HAPPCAP-AD –Human APPlication Combined Approach for Prevention of Alzheimer's disease

Description: To examine the feasibility and provide pilot data on effectiveness of a novel "real-life" personalized 24-months intervention for prevention of cognitive decline in middle-aged individuals (age 40-65-year-old) at high AD risk due to AD parental family history. We will implement an approach combining smartphone application ("Sheba Me-HaLev" application) with study team guidance (human-app combined approach). We hypothesize that daily risk-factors reports using the app will increase participant's engagement in the intervention and will enable the study team to accumulate health information, in order to improve support and counselling for improvement of risk factors. In addition to examining the feasibility of our approach, we will explore its effectiveness in both improving risk factors values, as well as improving cognitive function by comparing the HAPPCAP-AD intervention group to "control group". Last, our study will lay the foundations for a strong long-term large-scale preventive intervention in the future.  We will compare this group to a partially passive control.

Contact Person: Matatov Adar AD.Balance@sheba.health.gov.il

PI: Dr. Ithamar Ganmore