Scientific Publications

Pancreatic and duodenal homeobox gene 1 induces hepatic dedifferentiation by suppressing the expression of CCAAT/enhancer-binding protein beta. Hepatology (Baltimore, Md.) 2007;46(3):898-905.

2. Shternhall-Ron Keren; Quintana Francisco J; Perl Shira; Meivar-Levy Irit; Barshack Iris; Cohen Irun R; Ferber Sarah, 2007
Ectopic PDX-1 expression in liver ameliorates type 1 diabetes. Journal of autoimmunity 2007;28(2-3):134-42.

3. Meivar-Levy Irit; Ferber Sarah, 2006

Regenerative medicine: using liver to generate pancreas for treating diabetes. The Israel Medical Association journal : IMAJ 2006;8(6):430-4.

4. Sapir Tamar; Shternhall Keren; Meivar-Levy Irit; Blumenfeld Tamar; Cohen Hamutal; Skutelsky Ehud; Eventov-Friedman Smadar; Barshack Iris; Goldberg Iris; Pri-Chen Sarah; Ben-Dor Lya; Polak-Charcon Sylvie; Karasik Avraham; Shimon Ilan; Mor Eytan; Ferber Sarah, 2005
Cell-replacement therapy for diabetes: Generating functional insulin-producing tissue from adult human liver cells. Proceedings of the National Academy of Sciences of the United States of America 2005;102(22):7964-9.

5. Meivar-Levy Irit; Ferber Sarah, 2003
New organs from our own tissues: liver-to-pancreas transdifferentiation.
Trends in endocrinology and metabolism: TEM 2003;14(10):460-6.

6. Ber Idit; Shternhall Keren; Perl Shira; Ohanuna Zohar; Goldberg Iris; Barshack Iris; Benvenisti-Zarum Luna; Meivar-Levy Irit; Ferber Sarah,2003
Functional, persistent, and extended liver to pancreas transdifferentiation.
The Journal of biological chemistry 2003;278(34):31950-7.

7. Leibowitz G; Ferber S; Apelqvist A; Edlund H; Gross D J; Cerasi E; Melloul D; Kaiser N, 2001
IPF1/PDX1 deficiency and beta-cell dysfunction in Psammomys obesus, an animal With type 2 diabetes. Diabetes 2001;50(8):1799-806.

8. Ferber S, 2000
Can we create new organs from our own tissues? The Israel Medical Association journal : IMAJ 2000;2 Suppl():32-6.

9. Ferber S; Halkin A; Cohen H; Ber I; Einav Y; Goldberg I; Barshack I; Seijffers R; Kopolovic J; Kaiser N; Karasik A, 2000
Pancreatic and duodenal homeobox gene 1 induces expression of insulin genes in liver and ameliorates streptozotocin-induced hyperglycemia. Nature medicine 2000;6(5):568-72.

10.  Cohen O; Einav Y; Cohen Y; Karasik A; Ferber S, 2000
Implantation of rat insulinoma cell line into cyclosporine treated rats. Effect of the in vivo environment on beta-cell specific gene expression. Transplantation 2000;69(7):1464-70.

11. Seijffers R; Ben-David O; Cohen Y; Karasik A; Berezin M; Newgard C B; Ferber S, 1999
Increase in PDX-1 levels suppresses insulin gene expression in RIN 1046-38 cells. Endocrinology 1999;140(7):3311-7.

12. Mauda-Havakuk M, Litichever N, Chernichovski E, Nakar O, Winkler E, Mazkereth R, Orenstein A, Bar-Meir E, Ravassard P, Meivar-Levy I, Ferber S. Ectopic PDX-1 Expression Directly Reprograms Human Keratinocytes along Pancreatic Insulin-Producing Cells Fate. PLoS ONE 2011 6(10): e26298.

13. Meiar-Levy I, Sapir T, Berneman D, Weissbach T, Polak-Charcon S, Ravassard P, Tzakis AG, Mor E, Ricordi C, Ferber S. Human Liver Cells Expressing Albumin and Mesenchymal Characteristics Give Rise to Insulin-Producing Cells, Journal of Transplantation, 2011 vol. 2011, Article ID 252387, 12 pages.

14. Gefen-Halevi S, Rachmut IH, Molakandov K, Berneman D, Mor E, Meivar-Levy I, Ferber S. NKX6.1 promotes PDX-1-induced liver to pancreatic β-cells reprogramming. Cell Reprogram. 2010 Dec;12(6):655-64

15. Meivar-Levy I, Ferber S.  Adult cell fate reprogramming: converting liver to pancreas. Methods Mol Biol. 2010;636:251-83.

16. Meivar-Levy I, Aviv V, Molakandof K and Ferber S "Transdifferentiation of liver to pancreas cells".a new volume entitled "Reprogramming and Programming of Cell Fate" in "Methods in Molecular Biology", published by Humana Press, USA . Editor of the volume-Prof. Sheng D

17. Meivar-Levy I, Aviv V and Ferber S Adult cell reprogramming: Using Non-pancreatic cell sources to generate surrogate β-cells for the treatment of diabetes. Humana Press (a part of Springer Science) in a monograph entitled Stem Cell Therapy for Diabetes, in a series on Stem Cell Biology and Regenerative Medicine. Edited by Prof. Efrat S.

18. Aviv V, Rachmut IH, Rubinek T, Mor E, Meivar-Levy I, Ferber S, Exendin-4 promotes liver cells proliferation and enhances PDX-1 induced liver to pancreas transdifferentiation process. J Biol Chem  2009 284(48):33509-20.*