Dorit Omer, Ph.D Student
Telephone: +972-3-5305095
E-mail: dorit.omer@gmail.com
Research title:
"Reprogramming of human adult and fetal kidney cells for treatment of renal failure"
Main objective :
The main aim of this study is to reprogram epigenetically and genetically HAK and HFK cells, in order to provide them stemness properties. The reprogrammed cells will be test to their therapeutic potential in a mouse model of renal failure.
Education & Qualifications
2008 - Present PhD student
Studies toward PhD, Sackler Faculty of Medicine, Tel-Aviv University, at the Pediatric Stem Cell Research Institute, Sheba Medical Center, Israel. Supervisor, Dr. Benjamin Dekel MD, PhD;
Title: ("Transcriptional reprogramming of human adult and fetal kidney cells for treatment of renal failure").
2005 - 2007 M.Sc, Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Israel.
Thesis: "The Role of the breast and ovarian tumor suppressor, BRCA1, E3 ubiquitin ligase activity in cell cycle regulation and genomic stability". Dr. Ronit Yarden, thesis advisor Israel
Graduated with excellence
2002 - 2005 B.Sc, Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Israel.
Graduated with excellence
Academic and professional awards
2006 Scholarship
Scholarship for outstanding research from Asi Schneidman foundation, Israel.
2007 Best lecture award
Sheba Medical Center, Research day, Isreal.
2009 International travel award
Stem Cell Network, Canada.
2009 Stem cell research scholarship
Sackler faculty of medicine, Tel Aviv University, Israel.
2010 One of the 12 best posters
Sheba Medical Center, Research day, Isreal.
Lectures
April 2007
Oral presentation: "BRCA1 Regulates the Ubiquitination and Degradation of Cell Cycle Proteins via the Ubiquitin-Proteasome Pathway"
Meeting of the Cancer Biology Research Center in Ma'a lot, Tel Aviv University, Israel.
May 2007
Oral presentation: "Mapping the Domains of BRCA1 Necessary for its Function as an E3 Ubiquitin Ligase Towards Cell Cycle Proteins"
Research day, Sheba Medical Center, Israel.
December 2009
Oral presentation: "Re-Activation Of Dormant Renal Stem/Progenitor Genes in Somatic Human Kidney Cells via Transcriptional Reprogramming and Wnt Pathway Modulation"
The 2nd Young Investigators Stem Cell meeting, Bar-Ilan University, Israel.
November 2010
Oral presentation: " Oct4 Overexpression but Not Chromatin Modifying Agents Reprograms Adult Human Kidney Cells into a Renal Progenitor State"
ASN's 43rd Annual Meeting and Scientific Exposition, Denver, CO.
December 2010
Oral presentation: " Putting in reverse gear: ectopic expression of Oct4 but not chromatin modifying agents reprograms differentiated human kidney epithelia to a renal progenitor-like state"
The 3nd Young Investigators Stem Cell meeting, Sheba Medical Center, Israel
May 2011
Oral presentation: " Putting in reverse gear: ectopic expression of Oct4 but not chromatin modifying agents reprograms differentiated human kidney epithelia to a renal progenitor-like state"
Research day, Sheba Medical Center, Israel
Poster presentations
April 2007 - "The Role of the breast and ovarian tumor suppressor, BRCA1, E3 ubiquitin ligase activity in cell
cycle regulation and genomic stability" 8th Research fair, Sackler faculty of medicine, Tel Aviv
University, Israel.
May 2009 - "Transcriptional reprogramming of human kidney cells via chromatin modulation induces
embryonic renal progenitor and pluripotency genes" Sheba Medical Center, Research Day, Israel.
June 2009 - "Transcriptional reprogramming of human kidney cells via chromatin modulation induces
embryonic renal progenitor and pluripotency genes" 3rd International Stem Cells Meeting, Tel-
Aviv, Israel
November 2009 - "Transcriptional reprogramming of human adult and fetal kidney cells for treatment of renal
failure" 2009 Stem Cell Network Annual General Meeting, Montreal, Canada
April 2010 - "Transcriptional reprogramming of human adult and fetal kidney cells for treatment of renal failure"
Research fair, Sackler faculty of medicine, Tel Aviv University, Israel.
May 2010 - "Re-Activation Of Dormant Renal Stem/Progenitor Genes in Somatic Human Kidney Cells via
Transcriptional Reprogramming and Wnt Pathway Modulation" The 7th Annual Conference of the
ISGCT, Sheba Medical Center, Israel.
May 2010 - "Re-Activation Of Dormant Renal Stem/Progenitor Genes in Somatic Human Kidney Cells via
Transcriptional Reprogramming and Wnt Pathway Modulation" Sheba Medical Center, Research
Day, Israel.
Februery 2011 - "Putting in reverse gear: ectopic expression of Oct4 but not chromatin modifying agents
reprograms differentiated human kidney epithelia to a renal progenitor-like state"
ILANIT/FISEB 2011, Eilat, Israel
Publications
Metsuyanim S, Harari-Steinberg O, Buzhor E, Omer D, Pode Shakked N, Ben-Hur H, Halperin R, Schneider D, Dekel B. Expression of Stem Cell Markers in the Human Fetal Kidney. Plos One, July 2009.
Pode-Shakked N, Harari-Steinberg O, Haberman-Ziv Y, Rom-Gross E, Bahar S, Omer D, Metsuyanim S, Buzhor E, Jacob-Hirsch J, Goldstein RS, Mark-Danieli M, Dekel B. Resistance or sensitivity of Wilms' tumor to anti-FZD7 antibody highlights the Wnt pathway as a possible therapeutic target. Oncogene, April 2011
Buzhor E, Harari-Steinberg O, Omer D, Metsuyanim S, Jacob-Hirsch J, Noiman T, Dotan Z, Goldstein RS, Dekel B. Kidney spheroids recapitulate tubular organoids leading to enhanced tubulogenic potency of human kidney-derived cells. Tissue Eng Part A. 2011
Metsuyanim S, Harari-Steinberg O, Omer D, Buzhor E, Noiman T, Ben-Hur H, Vaknin Z, Schneider DF, Aronow BJ, Goldstein RS, Dekel B. Identification of human nephron progenitors capable of de novo generation of kidney structures. Submitted.
Omer D, Harari-Steinberg O, BuzhoR E, Metsuyanim S, Dotan Z, Zundelevich A, Gal-Yam E , Goldstein RS, Aronow BJ, Dekel B. Oct4 and not chromatin modifying agents reprograms human adult kidney epithelia to an intermediate progenitor state. submitted.
