Dr. Linda Rubinstein (PhD)
Email: linda.rubinstein@gmail.com
Phone: 03-5309350, 054-4707620
Position: Director of Research,
The Joseph Sagol Neuroscience Center
LinkedIn
Dr. Rubinstein’s lab aims to elucidate how environmental stressors and aging affect the brain and behavior. We use cutting edge behavioral and molecular methods to illuminate redox and immune dys-homeostasis in neurodegenerative disorders and in aging. We are particularly interested to uncover sex differences in neurodegeneration and neuro-inflammation. By combining behavioral cues and molecular markers, we aim to find early biomarkers predicting neuropathology. We work with in vivo transgenic animal models, as well as in vitro models, we also use extreme environments as a model for accelerated aging. Our research is relevant to neuroinflammatory pathologies including cancer, inflammaging, Alzheimer’s, Parkinson’s, ALS, MS, and depression.
Overall, our research aims to advance more inclusive predictive and personalized medicine.
Research Interests:
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Elucidate redox and immune dys-homeostasis in neurodegenerative diseases and in aging.
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Find early biomarkers and behavioural cues for neurodegeneration.
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Immune and redox modulation as a possible therapy for neurodegenerative pathologies.
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Sex-differences in neurodegeneration and neuro-inflammation.
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Underlying mechanisms of how environmental stressors affect brain and behaviour.
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Using extreme environments (e.g. space) as a model for accelerated aging.
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Space medicine, astrobiology, and space research.
Education:
2017-2021, Postdoc, Neurobiology, Behavior, Sex differences, Astrobiology, Translational physiology, NASA Ames Research Center, Mountain View, California
2016-2017, Postdoc, Biochemistry, Genetics, UC Berkeley, Berkeley, California
2009-2015, Ph.D, Microbiology, Molecular Biology Genetics, Tel Aviv University, Tel Aviv, Israel
2003-2006, M.Sc., Summa cum laude Medical Science, Physiology, Hebrew University, Jerusalem, Israel
1999-2003, B.Sc.,Biology, Hebrew University, Jerusalem, Israel
Affiliations:
The Joseph Sagol Neuroscience Research Center, Sheba
The Longevity Center, Sheba
The Multidisciplinary Gonda Brain Research Center, Bar Ilan
Member:
- Gravitational and Space Research (ASGSR)
- NASA Human Research Program (HRP)
- Society for Neuroscience (SFN)
- Wi-Space, Women in space industry network
- Alzheimer’s Association International Society (ISTAART)
- European Association for the Study of Diabetes (ESAD)
Research Grants & Awards:
2023-2025, Principal Investigator, Second Chance, Sheba grant
2023, Principal Investigator, AAIC early-stage scientist travel award
2019-2023, Co-investigator – NASA Human Research Program Hero Grant – Oxidative stress and the neuro-consequences of the spaceflight environment, immune dysregulation, and antioxidant dietary countermeasure efficacy, $1.6 million.
Collaborator – HRP Human Research Program Hero Grant, Cardiovascular responses to simulated spaceflight: molecular signatures and surrogate outputs to measure
CVD risk $200,000
2022-2025, Principal Investigator, New lab start-up fund + facilities, Sheba, Israel
2022, Acceptance into Space innovation workshop, Israel
2019-2022, Co-investigator – Ames Research Innovation Award (ARIA) Proposal – Therapeutic stromal cells for health in space, $50,000
Co-investigator– Mouse Circling Behavior in Space: Rewarding Behavior or Stress Response, tissue sharing
2018, Travel award + acceptance into Cold Spring Harbor highly
competitive training program: Advanced Techniques in Molecular Neuroscience
2017, Acceptance to the highly competitive NASA Post-doctoral
Program (NPP) based on submitting innovative research proposal, full stipend+ $10,000/year travel funds
2006, Summa cum laude M.Sc. Degree completion with excellence, Medical Science, The Hebrew University, Jerusalem, Israel
Publications:
Here is a link to the publications of Dr. Linda Rubinstein
