Sally Metsuyanim, Ph.D Student

Ph.D student Research title:

Isolation and Characterization of Human Fetal Kidney-Derived Renal Stem/Progenitor Cells for the Treatment of Renal Failure Main

objective :

The goal of this research is to identify and isolate stem/progenitor cells from human fetal kidney and test their therapeutic potential in a mouse model of renal failure.

Education & Qualifications

2007-2012          PhD student, The Mina & Everard Goodman Faculty of Life Sciences, Bar-Ilan

                         University, Ramat-Gan, Israel, and The Pediatric Stem Cell Research Institute,     

                         Sheba Medical Center, Israel. Thesis (Pending Approval):" Isolation and
                            characterization of human fetal kidney derived renal stem/progenitor cells for treatment
                            of renal failure". Prof. Benjamin Dekel and Prof. Ron Goldstein.

2001-2003          M.Sc, Faculty of Medicine, The Hebrew University of Jerusalem, Israel.

                            Thesis:" Effects of prenatal heroin on chick behavior and activation of PKCγ ". Prof.   

                            Joseph Yanai.

1997-2001          B.Sc.Agr. Faculty of Animal Sciences, Agriculture and Environment, The  

                           Hebrew University of Jerusalem, Israel.

Publications

Shabbeer S, Omer D, Berneman D, Weitzman O, Alpaugh A, Pietraszkiewicz A, Metsuyanim S, Shainskaya A, Papa MZ, Yarden RI. BRCA1 targets G2/M cell cycle proteins for ubiquitination and proteasomal degradation. Oncogene. 2012 Dec 17. doi: 10.1038/onc.2012.522.

Yarden RI, Metsuyanim S, Pickholtz I, Shabbeer S, Telio H, and Papa MZ. BRCA1-dependent Chk1 phosphorylation triggers partial chromatin disassociation of phosphorylated Chk1 and facilitates S-phase cell cycle arrest. Int J Biochem Cell Biol. 2012 Jun 26.

Noiman T, Buzhor E, Metsuyanim S, Harari-Steinberg O, Morgenshtern C, Dekel B, Goldstein RS. A rapid in vivo assay system for analyzing the organogenetic capacity of human kidney cells. Organogenesis. 2011 Apr-Jun;7(2):140-4. doi: 10.4161/org.7.2.16457. Epub 2011 Apr 1.

Buzhor E, Harari-Steinberg O, Omer D, Metsuyanim S, Jacob-Hirsch J, Noiman T, Dotan Z, Goldstein RS, Dekel B. Kidney spheroids recapitulate tubular organoids leading to enhanced tubulogenic potency of human kidney-derived cells. Tissue Eng Part A. 2011 Sep;17(17-18):2305-19. Epub 2011 Jun 14.

Pode-Shakked N, Harari-Steinberg O, Haberman-Ziv Y, Rom-Gross E, Bahar S, Omer D, Metsuyanim S, Buzhor E, Jacob-Hirsch J, Goldstein RS, Mark-Danieli M, Dekel B. Resistance or sensitivity of Wilms' tumor to anti-FZD7 antibody highlights the Wnt pathway as a possible therapeutic target. Oncogene. 2011 Apr 7;30(14):1664-80. Epub 2011 Jan 17.

Yarden RI, Friedman E, Metsuyanim S, Olender T, Ben-Asher E, Papa MZ. Single-nucleotide polymorphisms in the p53 pathway genes modify cancer risk in BRCA1 and BRCA2 carriers of Jewish-Ashkenazi descent. Mol Carcinog. 2010 Jun;49(6):545-55.

Pode-Shakked N, Metsuyanim S, Rom-Gross E, Mor Y, Fridman E, Goldstein I, Amariglio N, Rechavi G, Keshet G, Dekel B. Developmental tumourigenesis: NCAM as a putative marker for the malignant renal stem/progenitor cell population. J Cell Mol Med. 2009 Aug;13(8B):1792-808.

Metsuyanim S, Harari-Steinberg O, Buzhor E, Omer D, Pode-Shakked N, Ben-Hur H, Reuvit Halperin, Schneider D, Dekel B. Expression of Stem Cell Markers in the Human Fetal Kidney. PLoS One. 2009 Aug 21;4(8):e6709.

Strauss T, Metsuyanim S, Pessach I, Shuchan-Eisen I, Kuint J, Dekel B. Analysis of circulating hem-endothelial marker RNA levels in preterm infants. BMC Pediatr. 2009 Jun 25;9(1):42.

Pode-Shakked N, Metsuyanim S, Rom-Gross E, Mor Y, Eduard Fridman, Goldstein I, Amariglio N, Rechavi G, Keshet G, Dekel B. Developmental tumorigenesis: NCAM as a putative marker for the malignant renal stem/progenitor cell population. JCMM, 2008 J Cell Mol Med. 2008 Dec 16.

Metsuyanim S, Levy R, Davidovits M, Dekel B. Molecular Evaluation of Circulating Endothelial Progenitor Cells in Children Undergoing Hemodialysis and after Kidney Transplantation.Pediatr Res. 2008 Oct 10.

Metsuyanim S, Pode-Shakked N, Schmidt-Ott KM, Keshet G, Rechavi G, Blumental D, Dekel B. Accumulation of malignant renal stem cells is associated with epigenetic changes in normal renal progenitor genes. Stem Cells. 2008 Jul;26(7):1808-17. Epub 2008 May 8.

Dekel B, Metsuyanim S, Goldstein N, Pode-Shakked N, Kovalski Y, Cohen Y, Davidovits M, Anikster Y. Schimke immuno-osseous dysplasia: expression of SMARCAL1 in blood and kidney provides novel insight into disease phenotype. Pediatr Res. 2008 Apr;63(4):398-403.

Yarden RI, Friedman E, Metsuyanim S, Olender T, Ben-Asher E, Papa MZ. MDM2 SNP309 accelerates breast and ovarian carcinogenesis in BRCA1 and BRCA2 carriers of Jewish-Ashkenazi descent. Breast Cancer Res Treat. 2008 Oct;111(3):497-504. Epub 2007 Nov 18.

Dekel B, Metsuyanim S, Garcia AM, Quintero C, Sanchez MJ, Izraeli S. Organ-injury-induced reactivation of hemangioblastic precursor cells. Leukemia. 2008 Jan;22(1):103-13. Epub 2007 Sep 27.

Atwal GS, Bond GL, Metsuyanim S, Papa M, Friedman E, Distelman-Menachem T, Ben Asher E, Lancet D, Ross DA, Sninsky J, White TJ, Levine AJ, Yarden R. Haplotype structure and selection of the MDM2 oncogene in humans. Proc Natl Acad Sci U S A. 2007 Mar 13;104(11):4524-9. Epub 2007 Mar 5.

Dekel B, Metsuyanim S, Schmidt-Ott KM, Fridman E, Jacob-Hirsch J, Simon A, Pinthus J, Mor Y, Barasch J, Amariglio N, Reisner Y, Kaminski N, Rechavi G. Multiple imprinted and stemness genes provide a link between normal and tumor progenitor cells of the developing human kidney. Cancer Res. 2006 Jun 15;66(12):6040-9.

Yanai J, Huleihel R, Izrael M, Metsuyanim S, Shahak H, Vatury O, Yaniv SP. Functional changes after prenatal opiate exposure related to opiate receptors' regulated alterations in cholinergic innervation. Int J Neuropsychopharmacol. 2003 Sep;6(3):253-65.