Yael Mardor, PhD
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Email: yael.mardor@sheba.health.gov.il
Phone: Israel 03-5302993, International +972-3-530-2993
Position: Chief Scientist, Advanced Technology Center
Areas of Expertise: brain, brain tumors, MRI, drug delivery, cancer
Education: PhD in Nuclear Physics Tel Aviv University, Tel Aviv, Israel
Associate Professor of Oncology Tel Aviv University, Tel Aviv, Israel
Affiliations:
The Advanced Technology Center and Radiology Institute, Sheba Medical Center; Sackler School of Medicine, Tel-Aviv University
Research Interests:
Drug delivery into the brain, blood-brain barrier, brain MRI, brain tumors, cancer imaging
Publications:
Here is a link to the list of publications of Dr. Yael Mardor in PubMed. PubMed is a database of scientific articles in the fields of medicine and life sciences
Research Grants and Awards:
Years |
Investigator (Principal / other) |
Granted by Institute/Company |
Subject |
1998-2001 |
as part of a consortium |
the IZMEL program of the Israel Ministry of Industry and Commerce |
Tissue characterization and tissue viability. |
October 1999 |
PI |
Yael Research Fund |
Differentiation Between Malignant and Benign Tissues In Vivo Using DWMRS |
September 2000 |
PI |
Israel Cancer Research Fund |
Noninvasive Monitoring of Cancer and Therapy with Diffusion Weighted MR Methods |
October 2001 |
PI with Prof. Cohen |
Israel Science Foundation |
Tissue Characterization and Early Detection of Response to Therapy in Cancer Tumors Using Diffusion Weighted MRI |
2001-2002 |
PI with Prof. Cohen and Dr. Orenstein |
Adams brain research center, Tel-Aviv Univ. |
Tissue Characterization and Early Detection of Response to Therapy in Brain Tumors Using Diffusion Weighted MRI |
2002 |
PI with Prof. Ram |
Israel Cancer Association |
Convection-enhanced Taxol delivery in brain tumor patients, monitored by diffusion-weighted MR |
2002-2003 |
PI with Dr. Nissim and Prof. Hadani |
Internal grant, Tel-Aviv Univ. |
The protective effect of T cell mediated immunization on the extent of ischemic brain damage in a rat model, monitored by diffusion-weighted imaging (DWMRI) |
2002-2003 |
PI with Dr. Pfeffer, Dr. Orenstein and Prof.Ram |
Internal grant, Tel-Aviv Univ., |
Convection-Enhanced Taxol Delivery in Brain Tumor Patients, Monitored By Diffusion-Weighted MRI |
2004-2005 |
PI with Dr. Pfeffer |
Israel Cancer Association |
Pre-treatment Prediction of Brain Tumors Response to Radiation Therapy Using High b Value Diffusion-Weighted MRI |
2005-2006 |
PI with Prof. Ram |
Adams Center – Tel-Aviv University |
Convection-Enhanced Taxol Delivery: Increased Efficacy, Decreased Toxicity, |
2006-2007 |
PI |
Israeli Medical Corps |
DWMRI for the assessment of brain damage cause by Paraoxone poisoning and the efficacy of the conventional antidotal treatment |
2006-2007 |
PI with Prof. Ram |
EZVONOT - Israeli Ministry of health |
Convection-Enhanced Taxol Delivery: Increased Efficacy, Decreased Toxicity |
2006-2008 |
PI with Dr. Spiegelmann |
Israeli Ministry of health |
Pre-Treatment and Early Post-Treatment Prediction of Brain Tumors Response to Therapy Using Low and High b Value Diffusion-Weighted MRI |
2007 |
PI |
Israeli Medical Corps |
Using DMRI to assess brain damage caused by exposure to the organophosphate paraoxone |
2008-2009 |
PI |
Goldhirsh Fund |
Convection-Enhanced Delivery of High Viscosity Nano-Particles |
2009 |
PI |
Israeli Medical Corps |
Using DMRI to assess the efficacy of scopolamine in brain damage caused by exposure to the organophosphate paraoxone, on long-term follow-up |
2010 |
PI |
Israeli Medical Corps |
Using DWMRI to assess the efficacy of the novel prodrug "Gabctyzine" in brain damage caused by exposure to the organophsphate Paraoxone
|
2010-2011 |
PI together with Prof Shai Israeli and Bioline Ltd |
Chief Scientist - NOFAR |
siRNA against STIL for the treatment of glioma by convection-enhanced drug delivery |
2010-2011 |
PI |
Tel-Aviv University |
The effect of inusate temperature on convection-enhanced drug delivery and BBB in normal rat brain |
2010-2011 |
PI |
Israel Cancer Association |
The effect of infusate temperature on convection-enhanced drug delivery in normal rat brain |
2011-2012 |
PI with Dr. Volovitz (Tel-Aviv Medical Center) and Dr. Shamir (Veterinarian Hospital, Beit Dagan) |
Israel Cancer Association |
Development and use of a spontaneous model for brain tumors in dogs to model the effect of the 'Split immunity' method to immunologically treat brain tumors |
2012-2013 |
PI with Prof Yarden |
Sheba-Weizmann |
Enhanced BBB penetration of high/low molecular weight therapeutic agents, following intratumoral delivery of a peptide derived from HIV-1 Tat protein: A combined approach for the treatment of brain tumors |
2012-2014 |
PI with Dr Leor Zach |
Chief Scientist - KAMIN |
MRI-based vessel function maps for differentiating tumor from treatment effects in patients with brain tumors |
2013-2014 |
PI with Prof Tanne |
Sheba internal grant |
The application of delayed contrast extravasation CT for determining BBB abnormalities in cerebrovascular disease |
2013-2014 |
PI with Dr. Sagi HarNof |
Brain Stimulation Consortium |
The application of FUS for non-invasive neuromodulation |
2013-2015 |
with Prof Gershon Golomb (as subcontractor since we have an active Kamin) |
Chief Scientist - KAMIN |
Treatment of brain malignant neoplasms by convection-enhanced delivery of liposomal chemotherapy |
2014-2015 |
PI together with Dr. Sagi HarNof |
Brain Stimulation Consortium |
The application of FUS for non-invasive neuromodulation |
2014-2015 |
PI with Dr Itzik Cooper |
Sheba internal grant. |
Combined chemotherapy and local blood-brain barrier opening by CED of EA-HAS for the treatment of brain tumors |
2014-2016 |
PI |
Brainlab AG |
The application of delayed contrast MRI for differentiating tumor from treatment effects in brain tumor patients |
2015-2016 |
PI together with Dr. Sagi HarNof |
Brain Stimulation Consortium |
The application of FUS for non-invasive neuromodulation |
2015-2018 |
PI with Dr Itzik Cooper and Dr Leor Zach |
ISF |
point source electroporation for the treatment of brain tumors : mechanism and physiological effects |
2016-2017 |
PI |
TAU internal grant |
Application of machine learning algorithms for prediction of GBM tumor growth using advanced MRI techniques |
2016-2017 |
PI |
Brain Stimulation Consortium |
The application of FUS for non-invasive neuromodulation |
2017-2019 |
PI with Dr Itzik Cooper |
Chief Scientist - KAMIN |
Novel BBB-disrupting platform with chemoimmunotherapy against glioma |
2017-2020 |
Co-PI with Drs Cooper, Shahar, Fleminger and Lampl |
Ministry of science, technology and space |
Blood-Brain Barrier Function in TiO2 Nano-Particles-Induced Neurological deficits: Basic and Clinical Study |
2018-2019 |
PI with Dr Jair Bar |
MOH |
Application of delayed contrast CT for differentiating tumor/non-tumor tissues in patients with lung cancer |
2018-2021 |
PI with Dr Itzik Cooper |
Israel Science Foundation |
Impact of Fragmented Electric Fields on the Neurovascular Unit: Mechanisms of Action and Physiological Effects |
2019-2023 |
PI with Prof Miri Sklair |
Israel Science Foundation |
Development and application of advanced analysis platform for MRI-based blood vessel characterization in tumor/benign breast tissues for personalized patient management |
2020-2022 |
PI with Dr Shirley Sharabi |
Sheba Medical Center internal grant |
Point source electroporation for the treatment of brain tumors |
1989, Faculty of Exact Sciences excellence award
1992, Faculty of Exact Sciences excellence award
1995, Faculty of Exact Sciences excellence award
1997, Faculty of Exact Sciences excellence award
1999, Excellent poster presentation award at the research day of Sheba Medical Center, Israel: “Diffusion weighted proton MRS; Applications to cancer cell metabolism and oncologic pharmacology”, Y. Mardor, O. Kaplan, M. Sterin, J. Ruiz-Cabello, E. Ash, I. Ringel and J.S. Cohen.
1999, Excellent poster presentation award at the Annual meeting of the Israel society for physiology and pharmacology: “Diffusion weighted proton MRS; Applications to cancer cell metabolism and oncologic pharmacology”, Y. Mardor, O. Kaplan, M. Sterin, J. Ruiz-Cabello, E. Ash, I. Ringel and J.S. Cohen.
1999, Excellent poster presentation award at the sixth international congress on hormones and cancer: “Diffusion weighted proton MRS; Applications to cancer cell metabolism and oncologic pharmacology”, Y. Mardor, O. Kaplan, M. Sterin, J. Ruiz-Cabello, E. Ash, I. Ringel and J.S. Cohen.
2001, Excellent oral presentation at the research day of Sheba Medical Center, Israel: “Early Detection of Response to Radiation Therapy in Patients with Brain Malignancies Using Diffusion Weighted MRI”, Mardor Y, Raphael Pfeffer, Roberto Spiegelmann, Yiftach Roth , Stephan E Maier, Uzi Nisim, Raanan Berger, Ami Glicksman, Arie Orenstein, Jack S Cohen & Thomas Tichler
2002, Excellent poster presentation at the Annual Meeting of the Israeli Society of Oncology and Radiotherapy, Israel: “Early Detection of Response of Brain Malignancies to Radiation Therapy Using Diffusion Weighted MRI”, Mardor Y, Raphael Pfeffer, Roberto Spiegelmann, Yiftach Roth, Stephan E Maier, Ouzi Nissim, Raanan Berger, Ami Glicksman, Arie Orenstein, Jack S Cohen and Thomas Tichler
2007, Excellent resident oral presentation at the Annual Meeting of the Society of Oncology and Radiotherapy, Israel: Pre-treatment prediction of response to radiation therapy using complexity analysis of T2 MRI images
Lior Zach, Aharon Ocherashvilli, Dianne Daniels, Yiftach Roth, Raphael Pfeffer, Roberto Spiegelmann, Doron Dinstein, Goren Gordon and Mardor Y
2008, Excellent poster presentation at the Annual Meeting of the European Association of Neuro Oncology (EANO), Spain: Convection-enhanced delivery of IL4 pseudomonas exotoxin (PRX321): Increased distribution and MR monitoring
Mardor Y, David Last, Nina Merchant, Simon Denmead, Dvora Nass, Dianne Daniels and Zvi Ram
2010, One of the "50 influencing women 2010" of the Lady Globes Journal
2011, Young investigator award at the Global Academic Programs Conference (at MDACC): MRI for depiction of subtle BBB opening in GBM patients, Leor Zach, David Guez, David Last, Dianne Daniels, David Tanne, Chen Hoffman and Mardor Y
2014, Best abstract award at the annual meeting of the Israeli Society of Cancer Research (ISCR), Delayed contrast mri – a novel tool for decision making in neuro-oncology ISCR Leor Zach, David Guez, David Last, Dianne Daniels, Yuval Grober, Ouzi Nissim, Chen Hoffmann, Dvora Nass, Alisa Talianski, Roberto Spiegelmann, Galia Tsarfay, Sharona Salomon, Moshe Hadani, Andrew Kanner, Debora Blumenthal, Felix Bukstein, Michal Yalon, Jacob Zauberman, Jonathan Roth, Yigal Shoshan, Evgeniya Fridman, Marc Wygoda, Dror Limon, Tzahala Tzuk, Zvi R Cohen ,Mardor Y
2015, Oral presentation abstract selected as best of ASTRO at the Americal Society for Radiation Oncology (ASTRO) meeting. Delayed contrast MRI for differentiating brain tumors from treatment-effects in conventional and combined treatments. Mardor Y, Dianne Daniels, David Guez, David Last, Yuval Grober, Ouzi Nissim, Dvora Nass, Chen Hoffmann, Galia Tsarfaty, Alisa Talianski, Roberto Spiegelmann, Sharona Salomon, Andrew Kanner, Debora T Blumenthal, Felix Bukstein, Yigal Shoshan, Marc Wygoda, Dror Limon, Zvi R Cohen, Leor Zach.
2016, paper selected to be featured in the AJNR podcast. Early Biomarkers from Conventional and Delayed-Contrast MRI to Predict the Response to Bevacizumab in Recurrent High-Grade. Gliomas. Dianne Daniels, David Guez, David Last, Chen Hoffmann, Dvora Nass, Alisa Talianski, Galia Tsarfaty, Sharona Salomon, Andrew A Kanner, Deborah T Blumenthal, Felix Bokstein, Sagi Harnof, Daniel Yekutieli, Shani Zamir, Zvi R Cohen, Leor Zach, Mardor Y
2017, paper Selected for AJNR News Digest. Early Biomarkers from Conventional and Delayed-Contrast MRI to Predict the Response to Bevacizumab in Recurrent High-Grade. Gliomas. Dianne Daniels, David Guez, David Last, Chen Hoffmann, Dvora Nass, Alisa Talianski, Galia Tsarfaty, Sharona Salomon, Andrew A Kanner, Deborah T Blumenthal, Felix Bokstein, Sagi Harnof, Daniel Yekutieli, Shani Zamir, Zvi R Cohen, Leor Zach, Mardor Y
Patents:
- Patent # 28314 – COMPOSITION FOR IMPROVING EFFICIENCY OF DRUG DELIVERY, Mardor Y and Ram Z, September 2004 (PCT September 2005, approved in Israel on 2011, approved in USA on Dec 2012)
- Patent pending #39379 – ASSESSMENT OF BLOOD-BRAIN BARRIER DISRUPTION, Israeli D, Mardor Y and Volk T, May 2007 (PCT May 2008, approved in Israel Oct 2013)
- Patent #54509 – MAGNETIC RESONANCE MAPS FOR ANALYZING TISSUE, Zach L, Guez D, Last D, Daniels D and Mardor Y, Oct 2011 (patent approved in USA)
- Patent #56456 – MAGNETIC RESONANCE MAPS FOR ANALYZING TISSUE, Zach L, Guez D, Last D, Daniels D and Mardor Y, April 2013 (patent approved in USA)
- Patent pending - METHOD FOR CHANGING BLOOD BRAIN BARRIER PERMEABILITY, Mardor Y, Sharabi S, Daniels D, Guez D, Last D, Bresler Y, Cooper I, Dec 2017