The Laboratory of Molecular Biology of the Department of Surgery

Our lab studies mechanisms of immune suppression, focusing on those regulated by Myeloid Derived Suppressor Cells (MDSCs). MDSCs are a heterogenous group of immature myeloid cells with a potent immunosuppressive function, which have emerged as major regulators in various developmental and pathological conditions.

Utilizing a diverse set of tools, including in vivo and in vitro assays, flow cytometry, and advanced high throughput methods on both animal and human tissues, we investigate the role of MDSCs and the mechanisms by which they operate in cancer, organ transplantation, and liver regeneration.

With a strong “bench to bedside” orientation, the lab conducts both basic and translational research, and our main goal is applying knowledge obtained in the lab to clinical practice to improve patient diagnosis and treatment. As part of the Sheba surgical division, we have access to an unparalleled abundance of clinical samples, and we benefit from direct interaction with patients, which allows us to focus on the most burning clinical challenges.