The Tamman Cardiovascular Research Institute is committed to taking pioneering discoveries from the laboratory to the patient, and revolutionizing the treatment of cardiovascular disease through cellular and gene-based therapies. The Institute supports innovation, and excellence with technology-driven inter-disciplinary research teams of basic and physician scientists driving basic scientific inquiry towards future clinical applications in the diagnosis and treatment of cardiovascular disease.
Basic science is the foundation for numerous significant scientific advances in the field of cardiovascular medicine, The staff constitutes a multidisciplinary group, working on basic research in molecular biology and gene expression, cell biology, and tissue engineering in mouse, rat and pig models of disease, that include :
Cardiovascular Regeneration Laboratory (Prof. Jonathan Leor): Research focuses on the biology of myocardial infarction, heart failure, myocarditis and atherosclerosis, both in defining the molecular mechanisms that underlie the healing processes, and in developing molecular and cell-based approaches to improve repair.
Cardiovascular Genetic Laboratory (Dr. Michael Arad): Studies on understanding the genetic basis of different cardiovascular diseases and syndromes are crucial to our ability to contain, prevent and treat them.
Electrophysiology Research Laboratory: Studies on the regulated function of cell-membrane embedded tunnels that underlie the regulation of the electrical stimulation of the heart.
Atrial Fibrillation Research Laboratory: The Atrial Fibrillation Research Laboratory was established in January 2009, with the funding of The Rothschild Caesarea Foundation.
Translational Research: To improve human health, scientific discoveries from basic research must be translated into practical clinical applications. Regenerative medicine is an emerging interdisciplinary field of research and clinical applications focused on the repair, replacement or regeneration of cells, tissue, or organs. It uses a combination of approaches including soluble molecules, gene therapy, stem cell transplantation, tissue engineering, and the reprogramming of cells and tissue.
Our primary goal is to develop novel therapies to regenerate damaged tissue and overcome debilitating chronic disease.
Driven by this goal, we test new approaches for regenerative therapies using novel cell sources, genes, soluble molecules and biomaterials.
Laboratories will include: Cardiac Tissue Engineering: Tissue engineering is a relatively new discipline that combines isolated functioning cells and biodegradable three-dimensional (3-D) polymeric scaffolds
Laboratory of Mechanical Engineering and Fluid Dynamics [future]: To establish a laboratory which includes simulation software and flow testing facilities (pulse duplicator) for R&D in the fields of valvular heart disease, and vascular diseases as well as device testing (material fatigue testing).
