Flow cytometry and cell sorting

1. Cell-to-cell transfer of oncogenic molecules and miRNAs from cancer cells to lymphocytes: Our group has pioneered this field and our present aims are as follows:

• Systematically determine the role of this mode of cellular communication in cancer immuno-surveillance and -editing;

• Unravel the full spectrum of proteins and small regulatory RNAs that are transported at the immunological synapse; and

• Resolve the molecular mechanism(s) that facilitate this unique cell-to-cell signal transfer at the immunological synapse.

1. Translational Research in the field of regulatory T (Treg) cells: 

• Develop Good Manufacturingg Practice (GMP) grade protocols to generate Tregs ex vivo for "patient tailored" immunotherapy using novel technologies;

• Examine in "humanized" NOG (NOD/Shi-scid/IL-2Rγnull) mice the efficacy of ex vivo induced human Treg cells in preventing immune mediated target organ damage.

Group leader: Itamar Goldstein MD

Team: Helly Vernitsky, M.Sc. (PhD. student): Projects 1 & 2., Meital Nagar, M.Sc. (PhD. student): Project 2., Nir Rainy, M.Sc. (PhD. student): Project 1.