The Laboratory for Molecular Cell Biology
The biology, biochemistry and clinical applications of small non-coding RNAs. Small RNAs molecules play a major role in cell proliferation, differentiation and determination of cell fate and where also found to be involved in many types of cancer.
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Small double stranded synthetic RNA molecules (siRNAs) may serve as potentially specific target drugs. We are developing siRNA molecules that use new approach to deliver into cells and longer silencing effect.
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Psoriasis is a complex disease at the cellular, genomic and genetic level. The importance of miRNAs in human skin development was already shown. Study the involvement of miRNAs in the pathogenesis of psoriasis. We have found few miRNAs that were expressed differentially, between psoriasis to normal skin (figure 1). We are further exploring the involvement of these miRNAs in the development of the disease.
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Malignant melanoma is devestating skin cancer with a constantly increasing incidence worldwide. In recent years, it is becoming clear that aberrant expression of miRNAs has a role in cancerous transformation and progression. Our aim is studying the role of miRNAs in the pathogenesis of malignant melanoma. Should this be the case, our work will enlight potential novel therapeutic targets in melanoma.
Professor Sidi Yechezkel MD
Avni Dror PhD
Raya Leibowitz-Amit MD, PhD
Lab team: Lerman Gali - Ph.D student, Bonen Hamutal - Ph.D student, Mizrahi Adi - Ph.D student, Zehvi Liron - Ph.D student, Gembitz Anat - M.Sc. student, Sergeyev Victoria - technician
